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Well-powered, controlled trials are needed to confirm efficacy and safety, identify optimal subgroups, and evaluate long-term outcomes
The clinical justification must outweigh the increased risks and uncertainty associated with off-label combination use
377 Deleting mutant p53 The expression of p53 mutants induces several vulnerabilities, such as specific dependencies for survival
One potential advantage of berberine is that since it has a different mechanism of action from metformin and statins, it may be useful for patients who dont respond well to these first-line treatments
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