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In addition, tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, resulted in even more pronounced weight loss effects, suggesting a potential advantage over traditional GLP-1 RAs
A systematic review and meta-analysis published in BMC Gastroenterology found that constipation rates with GLP-1 receptor agonists were approximately 2.5 times higher than placebo groups
However, intramuscular shots are usually given in small volumes (a few milliliters), limiting the dose
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