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Could become the gold standard once approved

In these separate phase 3 trials, gastrointestinal side effects were reported more frequently with the highest dose of retatrutide than with tirzepatide

A medical consultation is important before starting treatment, especially for anyone with a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, certain endocrine cancers, pregnancy, breastfeeding, complex diabetes medication use, or a personal or family history of medullary thyroid carcinoma or MEN2

In contrast, major structural differences are observed in the stalk, ECL1, ECL3, and ECD (Fig