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10.1016/s0140-6736(20)32205-4 Lancet 54 SchererT.SakamotoK.BuettnerC

Therapeutic interventions AKI is increasingly emerging as a significant issue for patients, primarily attributed to the extensive employment of nephrotoxic agents in healthcare settings

However, individual case reports and patient forums occasionally mention musculoskeletal discomfort during GLP-1 therapy

Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig