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Bialik said her gastrointestinal (GI) issues left her feeling so weak and dehydrated that a nurse had to come to her home to administer an IV, as she was unable to keep down even a "sip of water." "What shocked me was how unsurprised my doctor and this nurse seemed," Bialik wrote

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Its effectiveness relies on being used alongside a healthy diet and regular physical activity

However, competition from newer therapies has reduced its relative adoption by nearly 18% between 2021 and 2025