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GLP-1 and GIP are incretin hormones that stimulate insulin secretion after an oral glucose load by binding GLP-1R, but both are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4)
e Department of Gastroenterology, University of Maryland School of Medicine, MD, USA (Hassan Ghoz) Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with gastrointestinal (GI) adverse effects, but real-world evidence about their incidence in patients with functional GI disorders is limited
6-8 One key misunderstanding is that this is a disease of just lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off
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