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At very high injected doses in animal studies, there are negative side effects and signs of toxicity.[ref] At human doses, side effects can include gastrointestinal upset when eating more cruciferous vegetables than you usually do
Reduces inflammation Not by suppressing your immune system like NSAIDs
Interestingly, Pit-1 also regulates GHRHR synthesis, as if there were some kind of feedback positive between them, and also induces its own expression
A separate 2025 PubMed-reviewed paper on BPC-157 in orthopaedic sports medicine noted that the peptide showed positive outcomes in 87.5% of reviewed knee pain cases though the paper called out heterogeneity in study design and dosing protocols
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