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We have seen this happen, and this can be particularly problematic if your kidney function is already lower due to CKD." Patients with advanced CKD (eGFR between 1530 mL/min/1.73 m) or end-stage kidney disease (eGFR below 15 mL/min/1.73 m) require close monitoring since clinical data in these groups is limited

Treatment always starts at a low dose and increases slowly over several weeks

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Patients with certain variants may experience more pronounced gastric slowing or earlier fullness, helping PlexusDx customize your starting dose and escalation plan for your unique physiology