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Owing to the rapid increased prevalence of T2D and obesity, worldwide, and the robust prevailing weight reduction interventions to overcome the obesity-related morbidities, biliary tract diseases especially cholelithiasis represents an overwhelming complication in clinical practice [2]
Additional approaches under investigation include Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-targeted genome editing in human induced pluripotent stem cell-derived hepatocytes [139]
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