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BBR dose-dependently inhibited IgE reduction in a non-cytotoxic manner (nearly 100% at 5 g/mL) and at 5 g/mL, inhibited X box binding protein 1 (XBP1), B-lymphocyte-induced maturation protein 1 (BLIMP1), and STAT6 suppression, and reduced mitochondrial oxidation rate of IgE-producing plasma cells in vitro (Fig
is supported by the National Natural Science Foundation of China (32371214)
ADVERSE REACTIONS Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B 12
However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice
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