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Large, blue-black, irregularly bordered lesion on the upper lip of a Japanese male patient

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Numerous studies have demonstrated the therapeutic potential of phytomolecules in preclinical cellular and animal PD models, with their ability to exert pleiotropic neuroprotective effects by targeting, inflammatory signaling, mitochondrial dysfunction, S aggregation, and key pathways including sirtuins and PI3K/Akt signaling ( Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis

Most safety information comes from preclinical studies and extrapolation from the known safety profiles of related compounds