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Pancreatic safety of incretin-based drugs FDA and EMA assessment

N Engl J Med 380(24):22952306 Zinman B, Wanner C, Lachin JM et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes

A compound that touches those systems may still produce pigmentation, but the interpretation changes

This overexpression of ACE-2, on the one hand, negatively regulates the production of proinflammatory cytokines, such as IL-1, IL-6, and TNF- (Mancini et al., 2020)