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Muscle weakness, including in the pelvic floor, may also arise if rapid weight loss leads to loss of lean muscle mass without adequate nutrition or strength training

Patients with MEN 2 require specialist endocrinology care and should discuss the risks and benefits of GLP-1 therapy with their specialist

However, metformin does not carry this warning, and there is no scientific evidence to suggest that grapefruit affects the safety or effectiveness of taking this medication