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JAMA Internal Medicine
These agents stimulate colonic contractions and can provide relief within 6-12 hours
That signal is preclinical only : Dihexa has never entered a human clinical trial, several of the foundational mechanism papers were retracted in 2025 for falsified/fabricated data [4] , and everything below reflects animal reference data and community conventions provided strictly for research and educational reference not medical advice or a recommendation to self-administer
Andrew Huberman: But I know people are probably desperate to know what if they don't have a sauna
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