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Subsequently, the study found that reducing the plasma LEAP2/ghrelin ratio reversed cognitive deficits in aged mice by restoring hippocampal neurogenesis, alleviating synaptic loss, and inhibiting neuroinflammation

(1995) characterized MT-2's binding affinities, establishing it as one of the most potent synthetic melanocortin agonists, with sub-nanomolar affinity at multiple receptor subtypes