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Cartilage or synovial membrane samples were embedded in paraffin, and 5 m sagittal sections were obtained using a Polycut E microtome

Several mechanisms have been proposed to explain the association between diabetes and cancer, such as hyperglycemia, hyperinsulinemia, increased bioactivity of insulin-like growth factor 1, oxidative stress, sex hormone dysregulation, and chronic inflammation [37]

These compounds can interact with the amino acid residues of proteins, mainly histidine, cysteine, and lysine, to form carbonyl derivatives known as advanced lipoxidation end-products (ALEs) (169)