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Como pptido de investigacin, la retatrutida acta simultneamente sobre tres receptores del sistema incretnico: el receptor de GLP-1 (pptido similar al glucagn tipo 1), el receptor de GIP (polipptido insulinotrpico dependiente de glucosa) y el receptor de glucagn
Measurable weight change often appears by 6 to 12 weeks, with greater change over months
found that resistance training programmes lasting more than 10 weeks added approximately 3 kg of lean mass on average, even in participants running a caloric deficit or using GLP-1 drugs
An interim analysis was planned after two thirds of the total events had accrued with clear stopping rules and an alpha spending function to account for this interim look (in fact, the interim analysis did not take place until 741 events, out of the planned 854, took place)
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