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Individuals seeking support for weight management, growth hormone deficiency, or metabolic conditions are encouraged to engage with their GP or a specialist endocrinologist, who can assess eligibility for licensed treatments through appropriate clinical pathways

6.2 Non-insulin agents Use of metformin should be considered for patients with insulin resistance and those who are overweight, although GI side effects that affect tolerability are often considered (40)

Clinical data shows that roughly 25-40% of patients report nausea during the first week, with intensity varying based on dose level, injection speed, and individual metabolism