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Consumer Results* Overall Skin Condition 87% felt skin was deeply moisturized* 84% felt more supple skin* 83% saw revitalized skin with a healthy glow* 81% felt skin was plumped* 77% noticed skin was visibly perfected* Advanced Claims 76% saw an improvement in firmness, tightness & fragile texture* 75% saw an improvement in skin elasticity & wrinkles* 74% noticed an improvement in skin crepiness* 70% saw an improvement in deep creases* 70% felt skin was lifted* *In a consumer study of 102 women after 28 days

In the Phase 2 trial, participants who started directly at 4 mg (without the 2 mg titration period) experienced nearly double the rate of gastrointestinal adverse events compared to those who started at 2 mg (Jastreboff et al., NEJM 2023)

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tirzepatides 1.01 nM is Willard 2020's low-receptor-density assay