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These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]
Splitting, chewing, or crushing the tablet also breaks down this barrier, making the drug less effective
Variants in your GLP1R gene (such as rs6923761) influence how sensitive your gut and brain receptors are to the medication, while GIPR variants affect your glucose regulation response
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