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Although those benefits have been demonstrated only for specific OMMs (that is, tirzepatide for OSAS and semaglutide for KOA), it is plausible that these effects are largely driven by weight reduction rather than by unique pharmacodynamic properties of each molecule 55,56
The choice of diluent matters significantly for multi-use research
Future studies with multiple time-points and different methods are needed to fully understand the temporal aspects of HIF-1 localization and translocation
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