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The proportion of patients achieving NASH resolution in the absence of fibrosis progression was 40%, 36%, and 59% for the 0.1, 0.2, and 0.4 mg semaglutide arms, respectively, whereas the corresponding rate in the placebo arm was 17% (Newsome et al., 2021)

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Yes, substantially

For broader questions about how safe these medications are in general, the SELECT trial data, and what the 2024 to 2026 evidence shows on the most-discussed concerns, see our separate guide on whether weight-loss injections are safe