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Chronic oral administration of high doses of levocarnitine in patients with severe renal impairment or end stage renal insufficiency (ESRD) and dialysis may induce an accumulation of the potentially toxic metabolites trimethylamine (TMA) etrimethylamine-N-oxide (TMAO), in how much these metabolites are normally excreted in the urine

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Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study