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3.2 TM6SF2 TM6SF2 gene, located on chromosome 19p13.3, encodes a protein involved in hepatic lipid metabolism and has been strongly implicated in MASLD pathogenesis (113)
While tirzepatide does not directly affect B12 absorption like metformin, reduced intake of animal productscommon during appetite suppressionmay lead to inadequate B12 levels
Patients on those medications should only receive B-Complex injections with close monitoring (and dosage adjustments of the anticonvulsant if needed)
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