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This frequency helps minimize the risk of irritation

Prostaglandin analogues are extremely efficacious but may induce conjunctival hyperemia, enhanced eyelash growth, and alterations in iris color, whereas -blockers may result in systemic cardiovascular or respiratory side effects in predisposed individuals [12, 15,16,17]

Thank you for kind response x keep mine in the fridge Thank you for taking time to answer x If you use hydroxocobalamin read the Patient Information Leaflet (PIL)