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Cartilage degeneration in KOA is caused by the destruction of the dynamic balance of chondrocytes caused by activation based on other different aspects, in which the matrix degrades enzyme production and exceeds the ability of chondrocytes to secrete matrix components ( Pathogenesis of knee osteoarthritis Among the various structures that make up the knee joint, damage to hyaline articular cartilage is the main cause of osteoarthritis
MOTS-C MOTS-C is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene
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