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The kidney-protective effects of GLP1-RAs are believed to result from reductions in inflammation and oxidative stress, in part through direct binding to glucagon-like peptide 1 (GLP1) receptors present on kidney glomerular and tubular cells [51]
The medication does not directly cause flares, and for many patients the weight loss benefits may actually help their colon health in the long run
Who might be a good candidate for a GLP-1 GLP-1 medications arent right for everyone, but they may be worth discussing with your healthcare provider if: You have PCOS and insulin resistance or prediabetes You have a BMI of 30+, or 27+ with other health risks Youve tried lifestyle changes and medications like metformin without success Youre not currently trying to conceive or pregnant GLP-1s are not recommended if youre pregnant, breastfeeding, or have a history of specific thyroid or endocrine cancers, or pancreatitis
Routine follow-up should address ongoing GI symptoms affecting quality of life, even if not severe
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