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Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

The FDA has evaluated BPC-157 as a bulk drug substance for compounding and raised questions about its safety data

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PTPs regulate signal transduction pathways involving tyrosine phosphorylation and have been implicated in the development of cancer (84, 85)