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Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs
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In chondrocyte cultures, GHK-Cu increased the expression of type II collagen, the main structural protein of hyaline cartilage, as well as aggrecan, the most important proteoglycan for the compressive resistance of articular cartilage
For histopathological evaluation, skin specimens were collected on Days 7, 14, and 21 using 4-millimeter punch biopsy instruments from different corners of the left-side wound of each rabbit, immediately after planimetry
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