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In: Feingold KR, Anawalt B, Blackman MR, et al, eds

In the landmark STEP 1 trial, published in the New England Journal of Medicine , 1,961 adults with a BMI of 30 or greater (or 27 or greater with comorbidities) were randomized to receive once-weekly subcutaneous semaglutide 2.4 mg or a placebo, alongside a lifestyle intervention