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The case for three times weekly dosing Once you reach steady state (typically after 5 to 6 weeks of daily dosing), blood levels of semaglutide remain relatively stable even with less frequent dosing

The 15 mg dose has the highest nausea incidence in the SURMOUNT trials (18% of patients at 15 mg versus 12% at 10 mg), and a restart after a gap can amplify that