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Patients in the ALC group also had scores on the FACT trial outcome index subscale (FACT-TOI), an overall measure of function, that were on average 3.5 points lower (worse) than those among their placebo counterparts (P = .03)

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Between 2012 and 2014, regulatory authorities approved phentermine/topiramate extended-release, liraglutide (3 mg/day), and naltrexone/bupropion extended-release, which achieved sustained weight loss (12)

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