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Both wild-type and hepsin / mice received an intraperitoneal injection of 2APB (20 mg/kg), followed by a dose of APAP (500 mg/kg) 2 h later (Fig

Int J Colorectal Dis , 2014;29(12):152734

Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment