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Transdermal estradiol, delivered through patches or gels, bypasses hepatic first-pass metabolism and is associated with meaningfully lower thrombotic risk than oral estrogen formulations [18]

Adverse psychiatric effects associated with GLP-1 RAs, including depression, anxiety, and suicidal ideation, are noted in pharmacovigilance analyses, with variations among different GLP-1 RAs

Weight loss itself is associated with significant IBS symptom improvement, and semaglutide's proven efficacy for sustainable weight reduction may provide indirect benefit to IBS sufferers

Researchers also observed shifts in glucose uptake and sirtuin activity (the SIRT1 longevity protein family) when NNMT was blocked