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Under the influence of endogenous or exogenous H 2 O 2 as well as DAMP (e.g., HSP70 and HMGB1), vitiligo patients skin NK cells and type 1 innate lymphoid cells (ILC1s) in patients with vitiligo are among the first to initiate the production of IFN- (Fig
However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.
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