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In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone
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Furthermore, its antioxidant properties offer protection against oxidative stress, while its modulation of growth hormone receptors hints at potential longevity benefits
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