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In colorectal cancer, the ER stress inhibitor 4-PBA effectively suppresses erastin-induced ferroptosis and downregulates the expression of nuclear factor E2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1)
The animal data suggest lean mass is preserved, but human body composition data is lacking
Author contributions LA designed the experiments
Collins RM Jr, Zielke HR, Woody RC: Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes
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