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Quantitative analysis showed that the numbers of survived SGNs were reduced significantly in peroxynitrite-treated groups in a dose- and time-dependent manner compared with the control group (Figure 2B), that is, the higher concentration of peroxynitrite and the longer processing time induced more SGNs loss
With more people staying on therapy longer, new indications on the rise and a strong pipeline ahead, employers need to take a sharper, more strategic approach to managing this drug class, she said
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For example, a patient with a high-sensitivity GLP1R variant might benefit from more gradual dose escalation to minimize gastrointestinal side effects, which in turn reduces nausea-related dehydration and kidney stress
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