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TGR5 reportedly couples to the Gs/cAMP pathway to mediate GLP-1 release from enteroendocrine cells (Katsuma et al., 2012)
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Notably, this effect was attributable in part to the preservation of skeletal muscle mass and improved distribution of body fluids
Clinical trials show semaglutide can be effective for weight loss, and hundreds of thousands of people around the world are using it for this purpose
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