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Some of these effects are in fact analogous to those previously observed by reducing beta cell/islet cholesterol with simvastatin: for example, both manipulations led to a reduction in GLP-1R plasma membrane lateral diffusion under vehicle conditions, as well as acute increases in GLP-1R-induced cAMP and islet insulin secretion responses

Also, individuals with pre-existing thyroid disorders are considered more susceptible to potential adverse effects of excess iodine (either hypo or hyperthyroidism) [5, 22]