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When to Discuss Side Effects with Your Provider and Dosing Adjustments Mild to moderate fatigue that improves within 24 weeks is common and generally does not require dose reduction

[66] Other medications with anti-androgen effects include flutamide and spironolactone, which can improve hirsutism

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What the Evidence Shows (and What It Doesnt) A recent real-world study (n = 94) on semaglutide + cyanocobalamin (compounded) showed average weight loss of ~4.11 kg (4.6%) in 3 months , along with favorable reductions in fat mass and improvements in body composition PubMed However, large controlled trials of this exact combination are lacking