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Steliou K, Faller DV, Pinkert CA, Irwin MH, Moos WH

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The Four Amino Acid Substitutions Mechanism of Stability Four targeted amino acid substitutions D-Ala (position 2), Gln (position 8), Ala (position 15), and Leu (position 27) give CJC-1295 Without DAC dramatically improved resistance to DPP-IV proteolytic cleavage compared to native GRF (1-29), which has a half-life of under 10 minutes