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Immunoblot of LDLR and SCARB1 in HeLa LDLR _KO (left) and SCARB1 _KO (right) cells expressing a sgRNA-resistant LDLR , SCARB1 cDNA or empty vector
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The primary aim of the trial was to evaluate the efficacy of Maridebart cafraglutide, administered once monthly, in achieving significant weight loss
Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature
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