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That distribution has been remarkably stable all year, even as the stock has fallen from $258 in June 2025 to $186 today, implying the implied upside in analyst targets has widened to nearly 141% of the current close
Discontinuation due to gastrointestinal side effects was approximately 4% with oral semaglutide in the PIONEER programme
The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research
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