retatrutide phase 2 obesity trial results meets primary endpoints in two III trials, reporting up to 22.6% weight loss – touchENDOCRINOLOGY retatrutide phase 2 trial obesity

Liver pathologies can also limit the storage of vitamin B12 in the blood and cause a deficiency

Such a non-protein cofactor is known as a "prosthetic group." R -lipoic acid functions as a prosthetic group for the biological activity of the following multienzyme complexes: The glycine cleavage system that catalyzes the decarboxylation of glycine coupled with the addition of a methylene group (-CH 2 ) to tetrahydrofolate to form 5,10-methylene tetrahydrofolate, an important cofactor in the synthesis of nucleic acids ( Figure 3 )

People with specific gastrointestinal problems, such as Crohns disease or celiac disease, or those who have undergone gastrointestinal surgery may have difficulty absorbing B12 from food and supplements

doi:10.1093/ajcn/86.3.718