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40 In diabetic models, peroxisome proliferator-activated receptor c coactivator 1a (PGC-1a), an important factor in diabetic mitochondrial biosynthesis, is often found to be abnormally expressed, whereas PGC-1a is critical for synaptic growth and CNS function
This has created a land grab for existing fill-finish capacity, with CDMOs like Lonza, Thermo Fisher, and WuXi Biologics significantly expanding their sterile injectable footprints to accommodate the GLP-1 surge
Taking a dose one day early may slightly increase gastrointestinal side effects such as nausea but is generally well tolerated
While findings remain preliminary, they have prompted further scientific exploration
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