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To test if MOTS-c can improve physical performance in mice that have been on a HFD, we fed young C57BL/6J mice a HFD, or a normal diet, for 2 weeks before initiating daily MOTS-c injections (15 mg/kg/day) for 2 weeks prior to a treadmill running test (Supplementary Fig
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This is a secondary effect of overall matrix improvement, not a direct pore-targeting action
2, indicating that the GLP-1RA group had a lower risk of MACEs during the follow-up period compared to the control group
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