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GIP receptor signaling GIP, produced by duodenal K-cells, shares insulinotropic properties with GLP-1 but exhibits distinct receptor expression patterns and physiological effects
On December 22, 2025, the FDA approved the first oral GLP-1 for weight loss and reduction of major adverse cardiovascular events (MACE), Novo Nordisks Wegovy
However, a crucial limitation of the above studies is that the endpoint was pathologic (described as asymptomatic chronic pancreatitis), referring to histologic changes, rather than clinical 26
Why the Confusion is So Common So if it's just water, why is there so much chatter online about spironolactone for weight loss
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