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Endocrinology and Metabolism Clinics of North America, 37(4), 811823
Time Sensitivity The medication should be refrigerated as soon as possible, ideally within an hour of arrival, to prevent any degradation
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Interestingly, fat appears to be a stronger stimulator of GIP secretion than carbohydrate (12, 13) [ Figure 1 Section A]
Dosing Comparison# Retatrutide Dosing# Based on Phase 2 clinical trial protocols (investigational only): Starting dose : 0.5 mg weekly subcutaneous injection Escalation : Gradual increase over 12-24 weeks to target dose (up to 12 mg) Target doses tested : 1, 4, 8, and 12 mg weekly Escalation rationale : Extended 24-week escalation for higher doses reduces GI side effects compared to faster 12-week escalation No commercial formulation exists
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