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10.1186/s13195-024-01666-7 Alzheimers Res
instead, they provide drug unpredictably, in a way that regulatorscorrectlycannot accept for dose-critical indications ( 5 Dose escalation, gastrointestinal class effects, and economic constraints When the elimination half-life is short and steady-state accumulation is negligible, the most intuitive response in oral peptide and protein development has been dose escalation
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The importance of targeting the underlying pathophysiology of T2DM rather than focusing management on reducing plasma glucose levels, as is currently recommended, has recently been debated [8]
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